Біосиміляри в терапії цукрового діабету 1 типу: потенційні ризики застосування в пацієнтів дитячого віку
Ключові слова:
цукровий діабет 1 типу, аналоги інсуліну, біосиміляри, імуногенність, антитілоутворення, діти та підліткиАнотація
Проблема використання біосимілярів інсуліну у хворих на цукровий діабет останніми роками набуває все більшої актуальності через закінчення терміну патентування найефективніших інсулінових препаратів, зокрема золотого стандарту базальної інсулінотерапії гларгіну. В огляді представлено аналіз особливостей перебігу цукрового діабету 1 типу у хворих дитячого віку в аспекті підвищеної імунної реактивності та активного продіабетогенного антитілоутворення. На підставі аналізу численних наукових досліджень обґрунтовано необхідність урахування високого потенційного ризику застосування у дітей та підлітків препаратів інсуліну з непередбаченими властивостями, що характеризує більшість відомих наразі біосимілярів інсуліну «Гларгіну».
Посилання
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